News Release
NEW SCIENTIFIC STUDIES ESTABLISH THE SAFETY OF REBIANA,
A SWEETENER FROM THE STEVIA PLANT
ATLANTA, Ga., WAYZATA, Minn., May 15, 2008 -
Research published electronically today in the peer-reviewed scientific
journal Food and Chemical Toxicology clearly establishes the
safety of rebiana (common or usual name for high-purity Rebaudioside
A from stevia) for general use to sweeten foods and beverages, according
to experts at Cargill and The Coca-Cola Company.
Rebiana is the first consistent, high-purity sweetener composed
of rebaudioside A, the best-tasting part of the stevia leaf. Beginning
in 2004, Cargill commissioned a rigorous safety evaluation program
for rebiana in consultation with leading scientists.
Cargill, in partnership with The Coca-Cola Company,
has developed rebiana as a natural, zero-calorie ingredient
which will be marketed by Cargill under the brand name TRUVIA.
"These newly published data complement the body of existing
scientific research on steviol glycosides, the sweet components of
the stevia leaf," said Leslie Curry, regulatory and scientific
affairs director, Cargill Food and Ingredient Systems. "The rebiana
research program affirmed positive safety data from earlier studies
on purified steviol glycosides and addressed unresolved questions
resulting from studies with crude stevia extracts."
"TRUVIA natural sweetener was developed to meet the strong
consumer demand for a natural, zero calorie way to sweeten foods and
beverages. Rebiana provides a new great tasting alternative
that meets that demand," said Zanna McFerson, business director
for Cargill Health and Nutrition. "The results of this research
program pave the way to bring this long sought after sweetener to
U.S. consumers."
Although stevia today is sold in the U.S. as a dietary supplement,
rebiana will be the first available sweetener for foods and
beverages that has been purified from the stevia plant. Unlike many
existing stevia products, which generally contain crude extracts of
the plant, rebiana is a fully-characterized product that is
consistent in quality and contains only the best-tasting components
of the stevia leaf.
"We are pleased that these studies have proved definitively
that rebiana is safe," said Dr. Rhona Applebaum, vice
president and chief scientific and regulatory officer of The Coca-Cola
Company.
Study Results
The rebiana safety evaluation program included metabolism and
pharmacokinetic studies, general and multi-generational safety studies,
intake studies and human studies. Cargill sponsored the studies to
affirm earlier safety findings for purified steviol glycosides, and
to confirm that rebiana is broken down by the body in the same
way as stevioside, which has been studied extensively. Rebaudioside
A -- the main component of rebiana -- is nearly identical in
chemical structure to stevioside.
| Study |
Top-line Findings |
Implications |
| Metabolism and pharmacokinetic studies |
- Metabolism of rebaudioside A is similar to that of stevioside
|
- Safety data from stevioside studies can be applied to rebiana
- The safety of rebiana is supported by a large
database of scientific research
|
| General safety |
- No negative effects on general health associated with doses
equivalent to a 150-lb person drinking more than 2,000 8-ounce
servings of a rebiana-sweetened beverage
- No treatment-related effects on any organ, including kidneys
and male reproductive organs
|
- Supports safety of high-purity steviol glycoside ingredients,
including rebiana
- Refutes outdated studies suggesting adverse effects of stevia
or stevioside on male reproductive organs (1985, 1999) or
on kidney function (1988, 1994, 1997)
- Rebiana does not affect general health or organ
function
|
Multi-generational/
reproductive toxicology |
- Daily consumption equivalent to a 150-lb person drinking
nearly 1,000 8-ounce servings of a rebiana-sweetened
beverage had no negative effects on general health, reproduction,
growth or development of adults or their offspring
|
- Refutes studies (1968, 1985, 1998, 1999) suggesting potential
adverse effects on male or female fertility, or health of
offspring
- Rebiana does not affect reproductive health or
health of offspring
|
| Chronic blood pressure study |
- Daily consumption of 1,000 mg rebiana -- equivalent
to drinking more than eight 8-ounce servings of a rebiana-sweetened
beverage every day -- for 4 weeks had no significant blood
pressure effects in healthy subjects with normal or low-normal
blood pressure
|
- Addresses questions raised by two Taiwanese studies (2000
and 2003) suggesting that stevioside (purity unknown) lowered
blood pressure in people with essential hypertension
- Rebiana does not affect blood pressure
|
| Chronic blood sugar study |
- Daily consumption of 1,000 mg of rebiana -- equivalent
to drinking more than eight 8-ounce servings of a rebiana-sweetened
beverage every day -- for 16 weeks did not affect blood sugar
control and was well-tolerated in people with type 2 diabetes
|
- Addresses questions raised by a single-dose study (2004)
suggesting that stevioside reduced levels of blood sugar after
meals in people with type 2 diabetes
- Rebiana does not affect blood sugar control in
people with type 2 diabetes
|
- In safety studies, daily consumption of rebiana equivalent
to a 150-lb person drinking between 1,000 and 2,000 8-ounce servings
of rebiana-sweetened beverage had no negative effects
on the general health, reproduction, growth or development of adults
or their offspring.
- In clinical studies, daily consumption of 1,000 mg rebiana
-- equivalent to consuming 29 packets of sweetener or drinking
approximately eight 8-ounce servings of a rebiana-sweetened
beverage every day for 4 or 16 weeks -- had no effect on blood pressure
in healthy subjects with normal or low-normal blood pressure; or
on blood sugar control in subjects with type 2 diabetes.
For more information, visit www.allaboutrebiana.com.
About The Coca-Cola Company
The Coca-Cola Company is the world's largest beverage
company, refreshing consumers with more than 450 sparkling and still
brands. Along with Coca-Cola®, recognized as the
world's most valuable brand, the Company's portfolio includes 12 other
billion dollar brands, including Diet Coke®, Fanta®, Sprite®,
Coca-Cola Zero®, vitaminwater®, Powerade®,
Minute Maid® and Georgia® Coffee. Globally, we are the No.
1 provider of sparkling beverages, juices and juice drinks and ready-to-drink
teas and coffees. Through the world's largest beverage distribution
system, consumers in more than 200 countries enjoy the Company's beverages
at a rate of 1.5 billion servings a day. With an enduring commitment
to building sustainable communities, our Company is focused on initiatives
that protect the environment, conserve resources and enhance the economic
development of the communities where we operate. For more information
about our Company, please visit our website at www.thecoca-colacompany.com.
About Cargill
Headquartered in Minneapolis, Minn., Cargill is a privately held international
provider of food, agricultural and risk management products and services.
With 158,000 employees in 66 countries, the company is committed to
using its knowledge and experience to collaborate with customers to
help them succeed. For more information about Cargill, visit: www.cargill.com.
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